Endocrine Abstracts

Introduction and aim: Cabergoline, a long-lasting dopamine-agonist, is generally considered to be the safety drug for the treatment of prolactinoma. But, use of long time and high dose cabergoline may be a cause of cardiac valvulopathy in patient with prolactinoma. In present study, we aim to determine serum N-terminal probrain natriuretic peptide levels in patients with prolactinoma who were treated with cabergoline.Materials and methods: Thirty patient...

Introduction: Pheochromocytoma (PHEO) is a rare tumor of chromaffin cells with variable clinical presentation. Adrenal PHEOs secrete excessive amounts of noradrenaline or of noradrenaline plus adrenaline, whereas extra-adrenal PHEOs (paragangliomas) mostly secrete noradrenaline alone due to lack of expression of phenylethanolamine-N-methyltransferase (PNMT), the key enzyme converting noradrenaline into adrenaline. We report two exceptional cases of paragangliomas responsible f...

Early detection is essential for curative cancer therapy and for achieving a decrease in cancer mortality. Markers for incipient stages of every type of cancer constitute therefore all oncologists’ dream. We have recently uncovered a new tumor marker, the FSH receptor (FSHR). Compared with the available markers, FSHR is found in a wide array of cancers, including eleven of the most frequent types. We have shown by various methods that FSHR is expressed in >1300 human ...

Introduction and aims: Thionamide may have immunosuppressive mechanisms. However, data suggest restoration of the immunological regulation as patients return to the euthyroid state may better explain remission, How successfully patients are kept euthyroid during a course of antithyroid drug therapy for Graves’ hyperthyroidism, and whether not continuously maintaining normal thyroid function is associated with a worse prognosis, is not known.Aims: 1)...

Objective: Reactive oxygen species and nitric oxide (NO) have recently been considered involved in the cardiovascular complications of patients with type 2 diabetes as NO is supposed to loose its physiological beneficial effects, due to the presence of oxygen radicals. For this reason, we tested the effects of L-arginine (ARG) and N-acetylcisteine (NAC) administration with the aim to increase NO physiological production reducing free radical formation.</p...

Aim: The work was initiated to study depression manifestations in patients with primary hyperparathyroidism.Materials and methods: Symptoms of anxiety and depression were assessed in 67 patients with primary hyperthyroidism aged from 16 to 30 years examined by means of Spielberger–Khanin’s test and Beck’s Depression Inventory.Problem of marginal psychoneurotic disturbances in patients with various somatic pathologies...

Introduction: The study aimed to analyze the efficiency of a concomitant N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac high-sensitivity troponin T (hs-cTnT) testing in diagnosing non-ST-segment-elevation myocardial infarction (NSTEMI) in patients initially negative for the standard fourth-generation assay of cardiac troponin T (cTnT), but with high clinical probability of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS).Meth...

Introduction: Post-prandial hyperglycaemia seems to play a pivotal role in the pathogenesis of cardiovascular complications of diabetes mellitus, as it leads to oxidative stress which in turn causes reduced NO bioavailability that produce endothelial activation.Aim: Aim of the study was to assure that the administration of N-acetylcysteine (NAC), thiolic antioxidant, is able to decrease oxidation status and endothelial activation after a high-gluc...

Objective: To determine the incidence of thyroid dysfunction in a cohort of patients started on amiodarone therapy at a cardiac clinic in Tashkent, Uzbekistan, which is believed to be an iodine- deficient area.Methods: Pharmacy records were used to obtain the names of patients who received amiodarone between 2006 and 2009.Results: The original sample size was 96; 3 patients were excluded to incomplete data and data analysis was com...

For metastatic phaeochromocytomas (PCCs) and paragangliomas (PGLs), there are currently no highly effective therapies available. We therefore investigated multiple novel molecular-targeted drug combinations in murine PCC cell lines and, most importantly, in human PCC/PGL 2D and 3D primary cultures (n = 18). Additionally, we analysed signalling pathway alterations as well as somatic mutations in the patients’ tumours in order to correlate these data with drug responsi...